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Given the relative difference in serine protease abundance between varying species of human schistosomes, other factors must participate in the cercarial penetration event

First, it directly addresses the root cause of mast cell hyper-reactivity: intracellular oxidative stress

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

& Mannervik, B