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Ruilope LM, Agarwal R, Anker SD, Bakris GL, Filippatos G, Nowack C, et al

It establishes the clinical context in which downstream metabolic adaptation, altered nutrient intake, and long-term physiological tradeoffs should be interpreted

This rigid approach often ignores individual physiology

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[1] [2] Clinicians should counsel patients about the importance of fluid intake and monitor for symptoms suggestive of nephrolithiasis, particularly in individuals with pre-existing risk factors for kidney stones

Clinical studies have shown that patients taking oral semaglutide achieved significant weight reduction over periods of up to 68 weeks