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Key GPX1 Variants rs1050450 (Pro198Leu) Leu allele carriers: Reduced GPX1 activity, increased oxidative stress

Transitioning to Maintenance Therapy Once the deficiency is managed, patients move to maintenance therapy

patients should strictly follow the prescribed schedule

Prolonged UV exposure accelerates aging, leading to fine lines, dark spots, and uneven texture

Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first

Before we can explore this key question, we first need to delve a little deeper into the function of vitamin B12 and the different reasons people have for taking it