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Some remarkable results are the decline of PSA after combination of metformin with bicalutamide after 8 weeks (42.1% bicalutamide + metformin vs 11.1% only bicalutamide) in PC patients with overweight (ClinicalTrial.gov ID NCT02614859), and with castration after 7 months (placebo PSA 58.2 ng/mL vs metformin PSA 8.36 ng/mL, ClinicalTrial.gov ID NCT01620593, [191]), and its detection in the prostatic tissue after consumption for 12 weeks, but without changes in tumor progression markers (ClinicalTrials.gov ID NCT01433913, [192])
L-Carnitine is a biologically active amino acid derivative that has a key role in the regulation of fatty acid metabolism and adenosine triphosphate formation in multiple organs
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This study aimed to investigate the possible myocardial protective effect of L-carnitine in children undergoing open-heart surgery by investigating L-carnitine effects on oxidative stress, apoptosis, and myocardial injury induced by cardiopulmonary bypass
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