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"When I treat patients in the diabetes clinic, I see a huge variation in response to these GLP-1-based medications and it is difficult to predict this response clinically," says endocrinologist Mahesh Umapathysivam, from Adelaide University in Australia

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Once inside the cell, the expectation is that haem-bound iron can be liberated through enzymatic cleavage of the porphyrin ring by haem oxygenase enzymes that are present in many bacterial species (Richard et al., 2019)

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The Role of Regulation in Addressing PBM Challenges Regulation plays an important role in addressing the challenges associated with PBMs