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Candidates were defined as therapeutic targets if they were significantly increased in tumors for a given subtype or differentiation state (adjusted P 0.05, Wilcoxon rank-sum with BenjaminiHochberg correction) and had a CRISPR gene effect score significantly below zero ( P 0.05)

84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

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600-1200mg daily (as determined by healthcare professional)

Metformin elicits antitumour effect by modulation of the gut microbiota and rescues Fusobacterium nucleatum -induced colorectal tumourigenesis

doi:10.1530/rep-14-0685