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10.1016/j.jcmg.2024.05.005 113 ShenX.WangH.WengC.HeY.ShaoX.LeJ.et al (2025)

Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

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These results indicate that the improvement of cognition and spatial memory of APP/PS1 mice is related an increase in neurons

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