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Wen HY, et al

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MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

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1 summarizes the several characteristics between single agonism using GLP-1 and dual agonism of GLP-1/GIP (i.e., tirzepatide) treatment

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