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Instruct patients to contact their health care provider as soon as possible if they experience symptoms of heart failure, including increasing shortness of breath, rapid increase in weight or swelling of the feet [see Warnings and Precautions (5.2)]
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Eventually: lethargy, stupor, coma
Once unfolded, the peptide loses its ability to bind growth hormone secretagogue receptors (GHS-R1a) even though the amino acid sequence remains chemically intact