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Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only

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I highly suggest opting for gentle non-toxic skincare products as to be kind to your skin microbiome and lessen your toxic load

The ring is usually present at the superior pole of the cornea first and then may progress to the inferior pole and finally circumferentially