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BH4 pairs with dihydrobiopterin (BH2) to form a redox cycle that scavenges endogenous oxidative radicals, protects lipid membranes, and inhibits ferroptosis [68]

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Similar to the protease discussed in the context of stroke, MS, and ALS, the cell-signaling analog of activate protein C, 3K3A-activated protein C, in addition to improving cerebrovascular integrity also diminished neuroinflammatory responses and slows the generation of amyloid-beta plaque buildup in AD model mice [129]

Essentially, your kidneys have to work harder, and in people who already have kidney issues, this extra work might speed up kidney function decline

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Glutathione's antioxidant mechanism can theoretically reduce effectiveness of pro-oxidant therapies like some cancer treatments