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For adults with type 2 diabetes and established atherosclerotic cardiovascular disease, high cardiovascular risk, chronic kidney disease, or heart failure, guidelines recommend GLP-1 agonists with proven cardiovascular benefit as preferred agents, independent of metformin use or baseline A1C

Cytosolic FOXO1 has been shown to be essential for autophagy induction by directly binding ATG7, independent of its transcriptional function, thus supporting the above mechanism

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At the level of subcellular compartments, such as the nucleus, mitochondria, lysosomes, endoplasmic reticulum (ER), Golgi apparatus, etc., these perturbations are sensed and activate the corresponding signal transduction pathways to generate the appropriate biological response

Autophagy 19 , 388400 (2023)