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Glucose sensing mediated by portal glucagon-like Peptide 1 receptor is markedly impaired in insulin-resistant obese animals

The appetite suppression provides a window of opportunity to establish sustainable habits

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This innovative therapy cleverly combines the "weight reduction and blood glucose lowering" effects of GLP-1R and GIPR co activation with the "enhanced insulin sensitivity and regulation of dyslipidemia" characteristics of PPAR activation

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