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and 5.14 kg and 1.89 kg/m 2 at 6 months [43]

Cell 84 , 46454659.e9 (2024)

Under normal circumstances, the liver processes nutrients from food and burns fat for energy

Wang Y, Tao X, Tang X-M, Xiao L, J-l S, Yan X-F, Li D, Deng H-Y, Ma X-R

To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH