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Into water and alcohols

The starting dose matters enormously for tolerability

An overdose is recognizable by the following signs: Shallow breathing, slow breathing or respiratory failure Small pupils Confusion Unresponsiveness or loss of consciousness Blue skin due to poor circulation In the case of an opioid overdose emergency, call 911 immediately

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The oxidized GSH dimer, GSSG, is formed from GSH and peroxide by the GP reaction

By highlighting mitochondria as both a mechanistic driver and actionable target, it offers a focused and translationally relevant perspective to guide future research and clinical strategies