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however, some contain nitrogen, oxygen, or sulfur

This is due to the absence of a 2-oxo-pyrrolidine core

Looking ahead, improving tissue- or cell-specific vector targeting, building high-throughput screening platforms for FAD-sensitive variants, and using patient-derived iPSC neurons for personalized preclinical testing will be pivotal in transitioning from experimental use to clinical implementation of integrated nutrient plus gene-editing therapies

At the same time, the diseases subclinical forms are even more frequent (~ 38%) [186]