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Interactions with medications Vitamin B12 can potentially interact with certain medications and prevent their efficacy or cause side effects

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Some people may experience temporary side effects after highdose injections, such as mild headache, nausea, or local skin reactions

While most patients tolerate B12 shots well, mild side effects can occasionally occur, including minor pain or redness at the injection site, mild diarrhoea, or, in rare instances, an allergic reaction