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MM was involved in conducting the phase 1 and 2 portions of this study, in performing the plasma L-citrulline and L-arginine analyses in phase 3, and was involved in manuscript preparation

That led to intense work for about a year that was initially predicting how bad it was going to be, and then ultimately giving these banks risk management tools to brace for impact

154 A major obstacle in this process lies in the limitations of animal models, which remain indispensable for mechanistic studies and early phase drug screening

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