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A series of 10 phase 3 multicenter, randomized clinical studies as part of the Peptide InnOvatioN for Early diabetes tReatment (PIONEER) program were conducted to compare the efficacy and safety of oral semaglutide with either placebo or active comparators [2131]

The safety data from animal studies is reassuring

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The study was a randomised, double-blind, placebo-controlled study of 50 people

oxidized phospholipids, in particular, have been shown to promote NETosis in arterial models, providing a biochemical basis for PMP-mediated neutrophil activation [48]