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IGF-1 was identified in 1957 by Salmon and Daughaday, and originally designated sulfation factor because of its ability to stimulate sulphate incorporation into rat cartilage

After a first 10-day period of intramuscular injections ALC 500 mg b.i.d., patients received an oral treatment consisting of one tablet of ALC 500 mg b.i.d., for 110 days

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