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The drug remains investigational for this use

Pennsylvania projects it will spend $1.3 billion on GLP-1 drugs this year

Among adults with type 2 diabetes and obesity (the primary populations receiving GLP-1-based therapy), baseline rates of back pain are particularly high due to biomechanical factors, inflammatory processes, and comorbid conditions

Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest

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