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One recent study used CRISPRa to successfully restore neuronal excitability and electrophysiological deficits in Scn2a +/- mice to wild-type levels, an effect that persisted until at least 3 and 8 months, respectively [78]

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The exact outcomes depend on the research model and study design, which is why DSIP continues to be explored in a variety of experimental settings

Very limited human data

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