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The SUSTAIN-6 cardiovascular outcomes trial demonstrated that semaglutide reduced major adverse cardiovascular events by 26% in patients with type 2 diabetes and existing heart disease

A complex interplay of gut hormones called incretins (glucagon-like peptide 1 [GLP-1] and gastric inhibitory polypeptide [GIP]) secreted from K and L cells of the small intestine in response to gastric nutrients, hepatic glucose and insulin, and gastric intrinsic and extrinsic factors as described in following sections bring about the fascinating gluco-gastric equilibrium [56, 57]

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This popular supplement, which touted celebrity spokespeople and sleek magazine ads, was pulled from shelves in 2009 after numerous reports of liver damage and even death

Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted