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It has also been shown that BBR is able to upregulate ADPN, IRS2, PI3Kp85, p-Akt (Ser473)/Akt, p-mTOR (Ser2448)/mTOR, PPAR and CPT1 levels and downregulate p-GSK3 (Ser9)/GSK3, ChREBP, SREBP-1C, ACC1 and FASN levels, and it is speculated that BBR regulates BMAL1-centered clock metabolic network and improves IR in HepG2 cells (Ahmad et al., 2025)