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NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone

These effects may also improve energy, metabolism, sexual health, and cardiovascular risk factors

NOTE: human trials are much more challenging to get approval for and are much more expensive to conduct

It may be necessary to attack each of these likely causes with separate drug development programs

For constipation GLP-1 medications slow digestion, which can cause constipation

Sleep, Stress Management, and Glutathione Restoration Sleep quality and stress levels profoundly influence glutathione status and overall antioxidant capacity