Mixing: Reconstitute gently by running media down the vial wall
The guide to tirzepatide injection in the thigh covers the specific positioning and needle angle for that alternative site
TL;DR: The GLP-1 receptor agonist landscape in 2026 spans four distinct compounds: semaglutide (selective GLP-1 RA, MW 4113.58 Da, injectable and oral), tirzepatide (dual GLP-1/GIP agonist, MW 4813.45 Da), retatrutide (triple GLP-1/GIP/glucagon agonist, MW ~4500 Da, Phase 3), and orforglipron (non-peptide oral GLP-1 agonist, MW 541.65 Da, FDA-approved April 2026)
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Some GLP-1 medications specifically injectable varieties also require refrigeration, much like insulin
The Bottom Line The GLP-1 drug class has genuinely transformed obesity medicine