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First, Use a body soap or body wash

Theres some evidence that long-term use of PDE5 inhibitors can result in a kind of tolerance, but the evidence for this is still somewhat poor.2 That said, if you were to develop a tolerance, graduating to a combination therapy might be a logical next step

Rahman I, Gilmour PS, Jimenez LA, Biswas SK, Antonicalli F, Aruoma OI

Start with the lower end of the dosing range (0.25mg daily) for your first protocol

We use carefully calibrated low doses as part of a holistic strategy that may support metabolic health while simultaneously addressing nutrition quality, movement patterns, hormonal balance, sleep optimization, stress management, and mindset

BMJ (clin Res Ed,)