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Medical Clearance: Ensuring safety and effectiveness, candidates should be in good overall health without significant contraindications

however, they had no significant effects on blood glucose control, lipid metabolism or insulin sensitivity in muscle, liver and adipose tissues (161)

IGFBP-1 gene is transcriptionally regulated by insulin in the liver [169]

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15 In the SURPASS-1 study, tirzepatide monotherapy at increasing doses of 5, 10, and 15 mg resulted in significant weight loss of 7, 7.8, and 9.5 kg, respectively, at week 40 in patients with T2DM, compared with a 0.7 kg decrease with placebo