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Another phase II trial showed that in patients with advanced HCC who had been previously treated with a multi-target kinase inhibitor sorafenib for HCC, PD-1 inhibitors pembrolizumab suggested an ORR rate of 17% and 77% of patients demonstrated sustained response for more than 9 months (Zhu et al., 2018)
10.1016/j.cell.2017.09.021 137 SuJ.MiaoQ.MiaoP.ZhaoY.ZhangY.ChenN.et al (2015)
These observations are provided for research context only and do not imply human or animal relevance
Diabetes type 2 and obesity are risk factors for cardiovascular disease, notably for hypertension and for heart failure (Coskun et al
Khanyi got her first big career break in 2004 when she starred in the popular soapie, Muvhango
Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes
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