Vitamin K2 (MK-4) Research 35 Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi Y
used APEX2 technology to explore the neighboring proteins of the copper chaperone Atox1 and conducted mass spectrometry analysis to identify a new nuclear copper-binding protein called cysteine-rich protein 2 (CRIP2), which interacts with Atox1 in the cell nucleus
In keratinocytes, GHK-Cu has been shown to downregulate inflammatory cytokine production in response to challenge including IL-1, TNF-, and IL-6, the inflammatory mediators most associated with the chronic scalp inflammation seen in androgenetic alopecia.4 In fibroblasts, GHK-Cu stimulates collagen and elastin synthesis, supporting the structural matrix that follicles depend on for anchoring and nutrient supply
GHK-Cu has potent anti-inflammatory properties, helping soothe the scalp and prevent inflammation from disrupting hair follicle activity
Rectal administration and in vivo distribution of EGCGZn suppositories To qualitatively evaluate the in vivo distribution and local retention behavior of EGCG-Zn suppositories, suppositories with different water contents (5%, 9%, and 12%) were administered rectally to mice, and the formulations were labeled with rhodamine B for fluorescence-based tracking of their release and localization (Fig
Sublingual glutathione is rapidly absorbed via the capillaries under the tongue