Review article: the design of clinical trials in hepatic encephalopathyan International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement
These include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist
CLASSIFICATION: SYNTHETIC PEPTIDE (REPAIR & RECOVERY) ACTIVE SUBSTANCE: THYMOSIN BETA-4 FORM: 2 ML VIAL x 5 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: 2.5-3 DAYS DOSAGE: MEN 7.66 MG/WEEK ACNE: NO WATER RETENTION: NO HIGH BLOOD PRESSURE (HBP): NO HEPATOTOXICITY: NO AROMATIZATION: NO MANUFACTURER: DRAGON PHARMA LABORATORY TESTED : VIEW LAB RESULTS CLASSIFICATION: NOOTROPIC PEPTIDE ACTIVE SUBSTANCE: SELANK FORM: 2 ML VIAL x 10 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: ~ 2-3 HOURS DOSAGE: MEN 250-500 MCG/DAY ACNE: NO WATER RETENTION: MINIMAL HIGH BLOOD PRESSURE (HBP): NO HEPATOTOXICITY: NO AROMATIZATION: NO MANUFACTURER: DRAGON PHARMA LABORATORY TESTED : VIEW LAB RESULTS CLASSIFICATION: SYNTHETIC MELANOCORTIN PEPTIDE ACTIVE SUBSTANCE: MELANOTAN 2 FORM: 2 ML VIAL x 10 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: ~ 3036 HOURS DOSAGE: 0.251 MG/DAY (LOADING), THEN 0.51 MG EVERY 23 DAYS (MAINTENANCE) ACNE: NO WATER RETENTION: NO HIGH BLOOD PRESSURE (HBP): NO HEPATOTOXICITY: NO AROMATIZATION: NO MANUFACTURER: DRAGON PHARMA LABORATORY TESTED : VIEW LAB RESULTS CLASSIFICATION: NOOTROPIC PEPTIDE ACTIVE SUBSTANCE: SEMAX FORM: 2 ML VIAL x 5 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: 2-3 HOURS DOSAGE: MEN 200-600 MCG/DAY ACNE: NO WATER RETENTION: NO HIGH BLOOD PRESSURE (HBP): NO HEPATOTOXICITY: NO AROMATIZATION: NO MANUFACTURER: DRAGON PHARMA LABORATORY TESTED : VIEW LAB RESULTS CLASSIFICATION: BODY PROTECTING COMPOUND ACTIVE SUBSTANCE: PENTADECAPEPTIDE FORM: 2 ML VIAL x 5 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: ~ 4-6 HOURS DOSAGE: 200-500 MCG/DAY ACNE: NOT REPORTED WATER RETENTION: NONE HIGH BLOOD PRESSURE (HBP): NO KNOWN IMPACT HEPATOTOXICITY: NONE AROMATIZATION: DOES NOT AROMATIZE MANUFACTURER: DRAGON PHARMA LABORATORY TESTED : VIEW LAB RESULTS CLASSIFICATION: PEPTIDE BLEND/HEALING & RECOVERY ACTIVE SUBSTANCES: - 5 MG THYMOSIN BETA 4 - 5 MG PENTADECAPEPTIDE FORM: 2 ML VIAL x 10 MG (LYOPHILIZED POWDER) ACTIVE HALF-LIFE: TB 500: 2-3 DAYS
and corresponding author NaveenGanesh Muralidharan ([email protected]) is senior manager of the MSAT team, all at AGC Biologics, 5550 Airport Boulevard, Boulder, CO 80301;
Under "Status," select Recruiting so you see only trials with open enrollment
doi:10.1002/jps.22639 Albert BB, Derraik JGB, Brennan CM, et al
