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Performance Q&A

The primary outcome for LEADER, SUSTAIN-6, EXSCEL, HARMONY Outcomes, REWIND, PIONEER 6 and AMPLITUDE-O was a three-point MACE, whereas ELIXA used a four-point MACE, including also hospital admission for unstable angina

The SUSTAIN 6 cardiovascular outcomes trial additionally demonstrated a reduction in major adverse cardiovascular events, which is particularly relevant given that insulin resistance is a key risk factor for cardiovascular disease

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Empower tirzepatide ODT has not undergone similar validation