A 2025 study published in JMIR Formative Research found that active subscribers on Second Natures semaglutide-supported programme achieved an average weight loss of 19.1% at 12 months, with 77.7% achieving at least 10% weight loss
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Certain variants are associated with a stronger biological appetite drive, reduced natural satiety signaling, and higher relapse risk after treatment stopssuggesting that continuous or near-continuous GLP-1 therapy may be your most realistic maintenance strategy
This allows your body and mood to stabilize on the new psychiatric medication, making it easier to identify which medication is causing any nausea, appetite changes, or fatigue
