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Most patients see gradual weight loss over weeks to months, with measurable changes often appearing within 8 to 12 weeks during dose escalation

However, genetic variations in GLP-1R sensitivity, DPP-4 enzyme activity, and metabolic efficiency can influence individual response

Patients with similar demographics and doses often experience notably different weight loss trajectories

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Symptoms are typically mild to moderate in severity, most pronounced during dose escalation, and tend to diminish over time