Discontinuation usually leads to gradual return to pre-treatment status over several months
Each component plays a distinct role: choline and methionine are involved in the transport and breakdown of fats in the liver, and inositol participates in cell signaling
Normal methylation cycles absolutely depend upon adequate levels of vitamin B12 as well as other key nutrients such as folate, riboflavin, B6, niacin, magnesium, and zinc
Its use for joint support is considered investigational and off-label
The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders
Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in ones diet that leads to a decrease in the consumption of such products such as a vegan , vegetarian, or low-fat diet can increase the chance of a person developing a B12 deficiency
