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Users with certain GLP1R rs6923761 variants, for example, may show different baseline GLP-1 receptor activity, which can influence both medication efficacy and carbohydrate tolerance

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Non-peptidic oral GLP-1RAs may eventually reduce supply pressures because they do not require peptide synthesis or cold-chain storage, but this will depend on scalable, cost-efficient manufacturing pathways

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doi: 10.1093/aje/kwae182 [DOI] [PMC free article] [PubMed] [Google Scholar] 404

The stomach muscles become weak and cannot push food through