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Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline

This recruitment is crucial for efficient mitophagy: depleting all three VDACs impairs Parkins targeting to defective mitochondria and mitochondrial degradation, yet each individual VDAC can redundantly support Parkin recruitment and mitophagy (147)

53 Subsequently, Wnt signaling directs LPC differentiation into functional hepatocytes, replacing damaged liver tissue and restoring organ function

doi: 10.1016/j.yexcr.2008.08.005 180

Studies have found for example that simvastatin inhibits the proliferation, invasion, and migration of the ovarian cancer cell lines OVCAR3 and SKOV3, thereby possibly exhibiting anti-metastatic effects also in ovarian cancer in vivo [88, 89]