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The FDA has noted that lack of therapeutic effect is "probably the biggest thing" clinicians observe with grey market products

Where we previously said, OK, there is kidney disease, there is liver disease, and so on, now we say there is a metabolic complex a problem with a common root, namely low-grade inflammation, and other metabolic disturbances common to all the tissues, and vascular problems common to all tissues, to the brain, to everything

Addressing the underlying immune dysfunction often improves energy as a secondary benefit

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Christina Joseph , Iosif Vaisman

It is now approved by the FDA and EMA and is marketed in the USA and the EU to treat an orphan disease by causing the patient to develop a natural tan without exposure to sunlight