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Differences in replication across loci may reflect ancestry-specific LD structure, variation in imputation coverage, sample size differences, and heterogeneity in phenotype definition across cohorts

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As an example, the half-life of carbamazepine is 1015 hours during maintenance therapy

This suggests new therapeutic strategies to control multiple pathological conditions that, although they display an immune component, are now known to be driven by abnormally activated fibroblasts