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Phase 2 data published in the New England Journal of Medicine demonstrated substantial weight reduction in some participants exceeding 20% of body weight over 48 weeks alongside improvements in cardiometabolic markers

ClinicalTrials.gov: A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight, TRIUMPH-1

After centrifugation at 10,000 g for 40 min, the supernatant was filtered through a 0.22 M PVDF filter (Millipore, USA)

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Mechanism: Inhibits the enzyme NNMT, leading to improved NAD+ metabolism and fat breakdown

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