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In the COMBINE 1 study, the Kyinsu group achieved an HbA1c reduction of 1.55 percent from baseline, compared with a 0.89 percent reduction in the insulin icodec group

They also lost some of the gains they had made in their cholesterol levels and blood pressure

Semaglutide is available in different forms, including a once-weekly subcutaneous injection and an oral tablet (branded as Rybelsus for type 2 diabetes)

JAMA 325 , 22622272 (2021)