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Huard, K

We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

The observed injuries in the lungs, heart, kidneys, and brain share a common mechanistic hallmark: glycocalyx shedding, increased vascular permeability, neutrophil adhesion, and oxidative stress [5, 17, 21, 104]

(2) Fiona OLeary and Samir Samman (2010) Vitamin B12 in Health and Disease Nutrients, 2010 Mar 5, Volume 2 (Issue 3), Pages 299316