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Li et al., 2023)

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In preclinical studies, FXR agonists, such as obeticholic acid, have been approved for the treatment of primary biliary cholangitis and have shown promising therapeutic potential in intestinal diseases like IBD, although their side effects and tissue specificity require further optimization [474, 475]

Others argue that as long as high-cost drugs exist, utilization management (UM) is necessary, and ePA is the ethical approach to implement UM transparently and fairly

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It has four main functions: anti-melanogenic, antioxidant, detoxifying, and strengthening the immune system