selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]
Megaloblastic Anemia : A condition with big, dysfunctional red blood cells
In the United States, between 3 to 6 % of the population are vitamin B12 deficient and up to 20% have marginally depleted levels (3)
Mechanistic Rationale NNMT consumes nicotinamide and SAM to produce 1-MNA and S-adenosylhomocysteine (SAH)
The Foundation of Safety: Why B12 Is Different To understand the safety of B12 injections, it helps to understand the vitamin itself
In D-galactose-induced aging mice, oral administration of the product significantly increased NAD+ levels in liver and adipose tissue, activated mitochondrial energy metabolism pathways, improved insulin sensitivity, lowered blood glucose and lipid levels, reduced visceral fat accumulation, and increased energy expenditure, alleviating fatigue and abnormal body weight associated with aging