Prominin 2 has a typical membrane topology with five transmembrane segments and two large glycosylated extracellular loops [74]
The TRIUMPH-4 results at 68 weeks (28.7% weight loss at 12mg) are the most mature Phase 3 data available
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Importante destacar que existe un circuito disociado en el tronco enceflico entre saciedad y aversin: mientras la activacin del NTS induce prdida de apetito sin efectos adversos, la del rea postrema puede generar nuseas, explicando los efectos secundarios gastrointestinales que presentan hasta un 40% de los pacientes con GLP-1RA
