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Unfortunately, there has been little research conducted specifically on the side-effects of MO, and further evidence is needed in the future to confirm the safety of MO

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Individuals with gastrointestinal disorders like celiac disease, Crohn's disease, or surgical alterations in the gastrointestinal tract may also experience impaired B12 absorption

Regular monitoring ensures that peptide therapy produces expected benefits and allows for protocol adjustments based on healing progress and individual response patterns

More recently, a comprehensive 2025 systematic review published by The ME Association evaluated the efficacy of various dietary supplements for ME/CFS