Rac1: Ras-related C3 botulinum toxin substrate 1
So far, studies have reported: Phase 2 (48 weeks): up to 24.2% average weight loss Phase 3 TRIUMPH-4 topline (68 weeks): 28.7% average weight loss (press release) What that looks like: If you start at 100 kg : 24.2% 24 kg average loss 28.7% 29 kg average loss Side effects and safety signals (what we know so far) Phase 2 (peer-reviewed) In the phase 2 trial, the most common adverse events were gastrointestinal and dose-related, typically mild to moderate
A Danish nationwide cohort study also reported a lower risk of corticosteroid use and hospitalization in IBD patients with DM2 undergoing GLP-1 RAs rather than other antidiabetic treatments (98)
Drug shortage Until recently, there was a shortage of FDA-approved injections that contain semaglutide, such as Ozempic
Thats the window where interventions like GLP-1s may matter most
The medical literature on GLP-1 receptor agonists reveals an uncomfortable truth: without intervention, a substantial portion of rapid weight loss comes from lean tissue