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The parameters below describe how it is used in supervised clinical care they are not a recommendation to self-administer, and we do not publish dosing for unsupervised use

In the acute administration paradigm, animals received a single intraperitoneal infusion (over 30 minutes) of cisplatin at doses ranging from 9 mg/kg to 15 mg/kg, and were monitored for up to 7 days

This ensures the fluid is distributed throughout the entire volume of the trigger point, not just in a single pocket

(Lausanne) 13 , 863184 (2022)

However, this broader action means a higher chance of gastrointestinal side effects early on

In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation