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Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)

Multiple rodent models of PCOS, capitalizing mainly on the impact of androgen excess at different developmental windows, with variable penetrance in terms of reproductive and metabolic impairment, have been used in translational studies, in order to capture the phenotypic heterogeneity of the syndrome 38

Leveraging these technological and strategic advancements allows researchers to bring innovative transdermal patches to patients faster and more reliably

For example, some medications can impact digestion or absorption in ways that may interact with GLP-1 activity

Conclusion The use of SGLTis and GLP-1 RAs represents a paradigm shift in the management of HF, moving beyond their traditional role as drugs for diabetes