In rats, gavage of trimetazidine (10 mg/kg/day) for 7 days prior to induction of acute myocardial ischemia preserved the mitochondrial structure, improved respiratory control ratio and mitochondrial complex I activity, as well as mitochondrial biosynthesis and fusion [137]
The cut-off distance for electrostatic interactions was set at 9 , with a switching function applied beyond 7.5
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As a consequence, they are not able to deliver enough oxygen into the bloodstream